makeO is a dental and skincare consumer health startup based in India, parent of the toothsi aligner brand, that offers clear aligners and clinic-based dental care for consumers.

This Startup Deep Dive explains what makeO does, how it makes money, who backs it, how it compares with rivals and what could go wrong, using publicly available information. It is educational and not investment advice. Last updated: October 2026.

makeO in Brief

• What it is: makeO is an Indian Dental tech, clear aligners company.
• Who it serves: patients, doctors, hospitals, diagnostic centres, insurers and employers.
• makeO is the parent company of the toothsi clear aligner brand.
• Reported funds are earmarked for an offline clinic network in India and Southeast Asia.
• January 2024: $16 million round led by 360 ONE Asset and Ashish Kacholia's office (reported).
• Funding: Over $100 million (reported).

makeO Quick Facts

Figures marked “reported” come from published reports and may differ between sources; “Not disclosed” means no reliable public figure was found.

What Is makeO?

makeO operates in the Dental tech, clear aligners space in India. Understanding a company like this starts with three questions: who is the customer, what painful problem is being solved, and why the solution is better than the alternatives. The sections below apply that lens to makeO.

• makeO is the parent company of the toothsi clear aligner brand.
• Reported funds are earmarked for an offline clinic network in India and Southeast Asia.

The Origin Story of makeO

Every company starts from a noticed gap and a team willing to commit to closing it. Strong origin stories are specific: a clear problem, a founding team with relevant skills, and an early product that real customers could test. Founder-market fit, meaning the team’s lived experience or technical depth in the domain, tends to predict how fast a young company learns.

• Founders: Dr. Arpi Mehta Shah, Dr. Pravin Shetty, Dr. Manjul Jain, Dr. Anirudh Kale.
• Founded in 2018 by orthodontists-turned-entrepreneurs (reported).
• In 2022 the founders created the umbrella brand makeO to go beyond aligners (reported).

Key Milestones and Challenges

No startup grows in a straight line. Early years usually involve slow adoption, product rewrites, hiring mistakes and funding gaps. In the Dental tech, clear aligners sector the common turning points are a first paying customer, a regulatory approval, a successful product demonstration or a funding round that lets the team invest ahead of demand. How a team responds to setbacks says more about resilience than any single headline.

• January 2024: $16 million round led by 360 ONE Asset and Ashish Kacholia's office (reported).
• Later: Rs 90 crore round led by Singularity AMC, with DSP family office, Genesis and Unispace Ventures (reported).

makeO Funding and Investors

Funding history shows how much outside confidence a company has attracted and how long it can operate before needing more capital. Figures below are reported and may differ between sources; valuation figures are estimates unless the company has confirmed them.

• $16 million round led by 360 ONE Asset and Ashish Kacholia's office (reported).
• Rs 90 crore (about $9.4 million) led by Singularity AMC (reported).
• Investors including Eight Roads Ventures, 360 ONE Asset and Paramark Ventures have put in over $100 million in total (reported).
• A separate report describes a Rs 54.7 crore round at a valuation over 50% lower than the $16 million round; reports differ on whether it is a distinct round.

How Does makeO Make Money? (Business Model)

A business model describes who pays, how often and how much it costs to serve them. Strong models show repeat usage, improving margins with scale and acquisition channels that do not depend only on paid spend. Weak models show one-off sales, rising costs and growth that stops when spending stops. For companies selling to patients, doctors, hospitals, diagnostic centres, insurers and employers, sales cycles and contract size matter as much as headline growth.

• Aligners plus an offline clinic network.

The Numbers: makeO Financials

Financial figures show whether growth is turning into a self-sustaining business. Small and private companies often disclose little, so any number below is included only if it was found in public reporting.

• Combined business crossed Rs 500 crore in revenue and turned EBITDA profitable (reported; period not specified).
• A data aggregator lists Rs 149.7 crore for FY25; reports differ.

Market Opportunity for makeO

Market size is easy to exaggerate, so a useful approach separates the total market from the portion a company can realistically reach with its current product and distribution. The main forces behind demand in this sector are rising chronic disease, growing health insurance penetration, government programmes such as Ayushman Bharat and the Ayushman Bharat Digital Mission, and the shift of care to digital and home settings. Each of these widens the opportunity, but capital efficiency and execution decide who captures it.

• Demand drivers: rising chronic disease, growing health insurance penetration, government programmes such as Ayushman Bharat and the Ayushman Bharat Digital Mission, and the shift of care to digital and home settings.
• Reach: How much of the market makeO can serve depends on its product readiness, distribution and regulatory approvals.

Technology and Product at makeO

Technology is rarely the whole moat, but it drives speed, cost and customer experience. A practical way to assess it is to separate the capability the company controls from the commodity infrastructure it rents. In this sector the important factors are clinical validity, data quality, integration with hospital and lab systems, and trust among doctors and patients.

• Core capability: Public detail on makeO’s technology stack is limited beyond company-stated descriptions.
• Assessment lens: clinical validity, data quality, integration with hospital and lab systems, and trust among doctors and patients.

Team and Culture at makeO

Teams are the most important and least measurable asset of a young company. Look at how complementary the founders’ skills are, how deep the second layer of leadership is, and how the company hires and retains specialists. Culture shows up in small repeated behaviours: how quickly bad news travels upward and whether commitments to customers are kept.

• Arpi Mehta is Group CEO.

makeO Competitors: Competitive Landscape

A fair competitive analysis names direct rivals, adjacent players who could move into the space, and the customer’s default alternative. Durable advantages include proprietary data or technology, licences and approvals, brand trust, switching costs and cost leadership.

• Direct competitors of makeO vary by product line; a verified rival comparison was not available from public sources.
• What to compare: Product readiness, pricing, customer base, funding runway and regulatory standing.

Risks and Challenges for makeO

• One report points to a down-valuation versus the earlier $16 million round.
• Revenue figures conflict across sources.
• Regulatory risk: medical devices, diagnostics, online pharmacy and telemedicine each face different and changing rules.
• Clinical and liability risk: errors in care, diagnosis or product quality can damage trust quickly.
• Data privacy risk: health records are sensitive, and breaches or misuse can bring legal and reputational harm.

Risk is not a reason to avoid a company; it is a reason to price it correctly and to monitor the right indicators over time. Regulation in this sector is shaped by the CDSCO, state health regulators, the National Medical Commission and the Digital Personal Data Protection Act.

makeO Growth Outlook: What to Watch

• Plan to expand clinics in India and Southeast Asia and weigh acquisitions of dental and aligner businesses (reported).
• Key indicators: patient or user volumes, repeat usage, gross margin, clinical outcomes and cost of acquiring each customer.
• Funding position: Whether makeO can reach its next milestone before needing new capital.
• Regulation: Changes from the CDSCO, state health regulators, the National Medical Commission and the Digital Personal Data Protection Act.

Industry Context: Where makeO Fits

India's healthcare market combines a large public system, a fast-growing private hospital sector and an increasingly digital layer. Government initiatives such as Ayushman Bharat and the Ayushman Bharat Digital Mission aim to widen insurance cover and create common digital health records, while telemedicine guidelines and the Digital Personal Data Protection Act shape how digital care and patient data can be used.

Demand is driven by chronic and lifestyle disease, an ageing population, rising insurance penetration and consumers who now expect to book, pay and consult online. Startups in this field compete on trust, clinical quality and convenience, and they must prove outcomes and safety as well as growth.

For readers new to this field, a useful habit is to separate announcements from evidence. A plan, a partnership or a funding headline describes intent, while a delivered product, a paying customer or an audited financial statement describes results. Comparing the two over time shows how reliably a company turns promises into outcomes.

Bull Case and Bear Case for makeO

An investment thesis is a short, testable statement of why a company could become far more valuable, together with what evidence would prove it wrong. The points below are general to this sector and are not forecasts for makeO.

Bull case

• Rising insurance cover and digital adoption expand the customer base.
• Strong clinical evidence builds trust with doctors and hospitals.
• Scale can improve unit economics in diagnostics and care delivery.

Bear case

• Regulatory changes can alter permitted products or business models.
• Customer acquisition costs can erode margins.
• A single safety or privacy incident can damage trust.

Lessons Founders and Investors Can Take from makeO

Studying a company in the Dental tech, clear aligners space offers lessons that go beyond any single firm. The points below are general lessons for the sector and are not claims about makeO.

• Trust is the real currency in healthcare, so quality control, clinical evidence and data protection must be built in from the start.
• Distribution through hospitals, clinics, insurers or employers can matter more than a standalone consumer app.
• Unit economics improve when repeat usage replaces expensive one-time customer acquisition.
• Regulatory approvals can take time, so timelines and cash planning should allow for them.
• Integration with existing hospital, lab and records systems reduces friction for adoption.

How to Evaluate makeO as a Startup

• Customer clarity: Can makeO name its customer and the problem it solves in one sentence?
• Evidence of demand: Look for repeat customers, signed contracts or measurable usage rather than announcements alone.
• Economics: Check whether margins improve as volume grows.
• Execution: Compare announced timelines with what has actually been delivered.
• Funding runway: Estimate how long current capital lasts at the present spending rate.
• Regulatory standing: Confirm required approvals are in place.
• Customer concentration: Check whether a few customers account for most of the revenue.
• Management depth: Look for experienced leaders beyond the founders and a stable core team.

The Takeaway

makeO is part of India’s growing Dental tech, clear aligners ecosystem. The useful lesson from studying it is the discipline of asking structured questions about customers, economics, advantage and resilience. Companies that answer them well, repeatedly and under pressure are the ones that endure. Readers should treat any single report, ranking or funding headline as one input among many, and should re-check key facts against recent company announcements. This article is educational and is not investment advice.

• Clear customers and repeat demand matter more than announcements.
• Regulation and capital needs shape how fast a startup in this sector can grow.
• Track a few leading indicators over time rather than one headline metric.

makeO FAQs: Frequently Asked Questions

What is makeO?

makeO is a dental and skincare consumer health startup based in India, parent of the toothsi aligner brand, that offers clear aligners and clinic-based dental care for consumers. It is profiled in the Startup Deep Dive series, which explains business model, funding, competitors and risks.

Who founded makeO?

makeO was founded by Dr. Arpi Mehta Shah, Dr. Pravin Shetty, Dr. Manjul Jain, Dr. Anirudh Kale, and the company reports a founding year of 2018.

How much funding has makeO raised?

Over $100 million (reported). Funding figures are reported and may differ between sources, so readers should check the latest company announcements.

How does makeO make money?

makeO earns revenue from its Dental tech, clear aligners products and services sold to patients, doctors, hospitals, diagnostic centres, insurers and employers. The exact revenue mix is described in the business model section and is not fully disclosed publicly.

Who are the competitors of makeO?

Competitors of makeO depend on the specific product line. A verified comparison was not available, so see the evaluation checklist above.

What are the main risks for makeO?

Main risks include medical devices, diagnostics, online pharmacy and telemedicine each face different and changing rules, funding and capital needs, competition and regulation by the CDSCO, state health regulators, the National Medical Commission and the Digital Personal Data Protection Act. This is educational content, not investment advice.

Related Startup Deep Dives: Agnikul Cosmos — IIT Madras spin-off building the Agnibaan rocket | Kalam Labs — Lucknow startup flying drones at near-space altitudes. Browse the full Startup Deep Dive series.

Source

Source: Publicly available data, published reports, industry research, and other credible sources.